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How to Microdose Mushrooms for Migraines: A Comprehensive 5 Step Guide

Blog title image for "How to Microdose Mushrooms For Migraines" showing dried magic mushrooms next to capsules full of psilocybin powder
Proper encapsulation provides consistent dosing


Migraines, affecting a significant portion of the population, are not just severe headaches but a complex neurological condition with a variety of symptoms. Traditional treatments often fall short, leading many to explore alternative therapies. Among these, microdosing psilocybin mushrooms has emerged as a potential remedy. This guide explores the nuances of microdosing mushrooms for migraine relief, backed by scientific insights and anecdotal evidence.

Understanding Microdosing and Migraines

Microdosing involves taking sub-perceptual doses of psychedelic substances, such as psilocybin mushrooms, which are known for their psychoactive properties. Unlike full doses that induce hallucinations, microdoses are small enough to avoid these effects while potentially offering therapeutic benefits. For migraine sufferers, microdosing could offer a new avenue for relief, impacting both the frequency and intensity of migraine episodes.

The Science Behind Microdosing for Migraines

Emerging research suggests that psilocybin, the active compound in magic mushrooms, may have significant effects on migraine relief. Studies indicate that psilocybin can influence serotonin receptors in the brain, which are often implicated in migraine pathology. This section will delve into the current scientific understanding of how microdosing psilocybin might alleviate migraine symptoms.

Dosage and Administration

Consistency in Treatment: Maintaining a Consistent Dosing Schedule

Consistency is key in microdosing for migraines. This section will discuss various dosing schedules and how to maintain them for optimal results.

How to determine the accurate dose and schedule

Magic mushroom dosing is a sensitive task. Inaccuracy in the dosage can bring the opposite result. So, we recommend collecting any magic mushroom in Canada from an authorized herbalist who can guide you on precise micro-dosing. After choosing what mushrooms you'd like to try, you need to choose the dose and schedule. Here are a few things to remember:

1. Start with a low dose: Beginning with a small amount is safe and helps you avoid potential risks. But you can increase the dose gradually depending on the tolerance level.

Anywhere between 100mg to 200mg of psilocybin is a good range for microdosing

Migraine microdosing chart for psilocybin

2. Wait between doses and avoid medications that could interfere with the psilocybin: The gap can be between 3 and 5 days. During this time, avoid any medication that can reduce the effect of the consumed mushroom.

Best Dosing Schedules:

Every 3rd Day Schedule: In this schedule, you take a microdose every third day. For example, if you start on Monday, you dose on Monday, then take two days off (Tuesday and Wednesday), and dose again on Thursday.

4 Days On/3 Days Off Schedule: This schedule involves microdosing for four consecutive days, followed by three days off. For instance, you dose from Monday to Thursday, then take a break from Friday to Sunday.

Here are two dosing schedules recommeded by the best research and experience

Optimal psilocybin microdosing schedule chart

3. Monitor the effect: Monitoring the effect is important to determine an accurate dose. Note the impact of mushrooms before, during, and after consumption precisely. The better you can track the effect, the more accurate your dose will be.

Again: For more detailed information, read our publictation: "The comprehensive Guide To Microdosing"

Recommended Dosages for Migraine Relief

  • A typical microdose ranges from 0.1 to 0.5 grams of dried mushrooms, but this can vary based on individual sensitivity and mushroom potency. For migraine relief, dosages might need to be adjusted, and this section will provide guidelines on finding the right dose.

Methods of Microdosing

  • Psilocybin can be ingested in various forms, including capsules, teas, and edibles. This subsection will explore these methods, discussing their pros and cons, and how they might affect the experience of microdosing for migraines. Your choice should be one which you feel comfortable to consume.

The 5 Step Process

Here are the steps to follow for consuming pscychedelic mushrooms for migraine relief.

1. Find out an appropriate microdose:

First, you must understand your tolerance level to magic mushrooms and set a dosage accordingly. Mushroom’s microdose ranges from 50mg to 500mg. If you are a beginner, a lower dose is suggested. You can increase the dose gradually depending on the tolerance level. 

2. Be accurate in measurement

Accurate dosage of mushrooms provides therapeutic benefits, whereas wrong doses can create hallucinations. So, you must count the measurement seriously. For the highest measurement accuracy, we suggest using a sensitive scale. 

3. Make a micro-dosing schedule

Like the dosage, determining a suitable schedule is also essential. It simply means creating a weekly routine of microdosing for migraines. The common schedule for mushroom consumption is 1 to 4 days a week. But you can customize it based on your tolerance level.

4. Choose a suitable consumption method

Magic mushrooms can be consumed in various ways. The consumption method depends on your personal preference. They are available in dried, gummy and powder forms. Choose one that you feel comfortable consuming.

5. Note the effects in a diary after consumption

Tracking the mushroom’s action on your body is crucial for understanding the impact. Note the dosage and consumption time and its effect on migraine. Also, record if you notice any change in mood and energy level. It helps you perfect the dosage and routine for maximum effectiveness.

Note: For more detailed information, read our publictation: "The comprehensive Guide To Microdosing"

Best 3 support mushrooms for microdosing and migraines: 3 Popular Varieties

Various strains of non-psychoactive mushrooms can be used in conjunction with magic mushrooms to help ease migraines. Their effects on individuals can vary. But all were found to be effective for the pulsating pain. Here are the three most common mushrooms used for migraines.

Lion’s mane

The strain has a high level of inflammation-reducing effects. It improves your sleep quality which can assist in migraine relief. The mushroom is also supportive of the nervous system.


It also contains powerful anti-inflammatory properties. The mushroom helps you manage stress and reduce anxiety. It can relax your nervous system, which is beneficial for migraines.


This strain is known for its anti-inflammatory properties and pain-relieving effects. The mushroom is also effective against migraines.

Higher Doses and Supervision

When to Consider Higher Doses

While microdosing involves taking sub-perceptual amounts of psilocybin mushrooms, there are instances where slightly higher doses might be more beneficial for migraine relief. These doses, while still not high enough to induce a full psychedelic experience, can potentially offer more pronounced therapeutic effects.

Identifying the Need for Higher Doses:

  • Assessing Effectiveness: If microdosing has not significantly impacted your migraine symptoms, a slightly higher dose might be considered.

  • Personal Tolerance: Individual tolerance levels can vary greatly. Some may require a higher dose to achieve the desired therapeutic effects.

  • Consultation with Professionals: Before increasing your dose, it's advisable to consult with a healthcare provider or a specialist in psychedelic therapy.

How to Safely Experiment with Higher Doses:

  • Gradual Increase: Any increase in dosage should be gradual. This cautious approach helps in assessing how your body reacts to the higher dose.

  • Monitoring Effects: Keep a detailed record of any changes in migraine symptoms, mood, cognition, and overall well-being.

  • Set and Setting: Ensure you are in a comfortable and safe environment when experimenting with higher doses until you get comfortable with the new dosing.

Seeking Support and Supervision

When considering higher doses of psilocybin mushrooms for migraine relief, it can be helpful to have professional guidance and a supportive environment. This ensures safety and enhances the therapeutic potential of the experience.

Importance of Professional Guidance:

  • Medical Supervision: A healthcare professional can provide valuable insights into how higher doses of psilocybin might interact with your specific health condition and any medications you are taking.

  • Therapeutic Support: Mental health professionals experienced in psychedelic therapy can offer support before, during, and after your higher-dose sessions, helping you integrate the experience into your migraine management strategy.

Creating a Supportive Environment:

  • Physical Safety: Choose a setting where you feel safe and comfortable. This could be your home or a professional setting designed for psychedelic experiences.

  • Emotional Support: Having a trusted friend, family member, or therapist present can provide emotional support and reassurance.

  • Post-Session Integration: Higher doses can lead to more profound experiences. Having someone to discuss and interpret these experiences with can be invaluable for integration and therapeutic benefit.

In summary, while higher doses of psilocybin mushrooms might offer enhanced benefits for migraine relief, they should be approached with caution. Professional guidance and a supportive environment are essential to ensure safety and maximize the therapeutic potential of the experience.

Personal Stories and Community Insights

Anecdotal Evidence

Personal anecdotes and experiences play a crucial role in understanding the real-world impact of microdosing mushrooms for migraines. These stories often provide a more relatable and humanized perspective on the practice, offering insights that scientific studies may not capture.

Sharing Personal Journeys:

  • Diverse Experiences: Accounts from individuals who have tried microdosing for migraines can vary widely, reflecting the personal nature of both migraines and psychedelic experiences.

  • Success Stories: Many individuals report significant reductions in migraine frequency and intensity, along with improved mood and cognitive function.

  • Challenges and Setbacks: It's also important to acknowledge stories where microdosing did not meet expectations or led to undesirable effects, providing a balanced view.

Learning from Personal Narratives:

  • Dosage and Frequency: Personal stories can offer practical advice on finding the right dosage and frequency for microdosing.

  • Lifestyle Integration: These narratives often include tips on integrating microdosing into daily life and managing expectations.

Insights from Online Forums and Communities

Online forums and communities dedicated to microdosing and psychedelic experiences are treasure troves of shared knowledge and advice. These platforms provide a collective wisdom that can be invaluable for both newcomers and experienced microdosers.

Gathering Community Wisdom:

  • Common Themes: Discussions often reveal common experiences and challenges faced by those microdosing for migraines, such as finding the right strain or dealing with legal concerns.

  • Tips and Tricks: Experienced microdosers frequently share their tips for effective dosing, managing potential side effects, and enhancing the overall experience.

  • Support and Encouragement: Online communities offer a sense of belonging and support, which can be particularly helpful for those new to microdosing.

Summarizing Forum Insights:

  • Best Practices: Compiling the best practices and advice from various forums can provide a valuable resource for readers.

  • Emerging Trends: Keeping an eye on new discussions and trends within these communities can help stay updated on the evolving practices and understandings of microdosing for migraines.

In conclusion, personal stories and community insights are integral to comprehending the multifaceted nature of microdosing mushrooms for migraines. They provide practical, real-world perspectives that enrich our understanding beyond clinical research, offering a more comprehensive view of this emerging practice.

Some online resources and forums:

  1. A website dedicated to helping fight migraines has several articles regarding psilocybin for migraine relief:

  2. Article on Shroomery Forum that discusses psilocybin & migraines:

  3. A search in blueligh forum for psilocybin & migraine:

Legal and Safety Considerations

Minor side effects after consuming magic mushrooms are pretty minimal. They may include nausea & dry mouth and in extreme cases, vomiting, weakness, etc. You should be aware of these issues so you understand what it is if it occurs. It will just pass with time but some sensitive folks claim that sipping ginger tea along with their microdose will prevent or alleviate any nausea.


  • Mushroom identification is a challenging task. Sometimes, useful and toxic strains look similar and need expert eyes to distinguish. Wrong or poisonous mushroom selection and consuming them can cause severe illness, even death.

Unpredictable effect:

  • Different mushrooms may have divergent effects on individuals. So, predicting the positive and negative effects after consumption is another challenge. Magic mushrooms can cause hallucinations, anxiety and panic attacks. This is where proper dosing and intention setting come in.

Interaction  with medicines:

  • Some strains can be reactive to your regular medications. When consumed simultaneously, you may notice several side effects. Sometimes, specific drugs can reduce the potency of mushrooms and make them inactive.

Legal risk:

  • Consuming such mushrooms can be illegal in some countries and regions. Before considering them, you need to know the local legality of those strains to avoid unwanted hassles.


Microdosing mushrooms presents a promising, albeit experimental, approach to migraine relief. While it offers potential benefits, it's important to approach this practice with caution, informed by research, personal tolerance, and legal considerations. It is always advised to consult an expert for personalized guidance before microdosing. If you are planning on micro-dosing mushrooms in Canada, find a reputable herbalist for better results.

FAQs: Microdosing Mushrooms for Migraines

1. What is the recommended dosage for microdosing mushrooms to treat migraines?

The recommended dosage for microdosing mushrooms, specifically for migraines, typically ranges from 0.1 to 0.5 grams of dried mushrooms. However, this can vary based on individual sensitivity and the specific strain of mushroom used. It's important to start with a lower dose and gradually adjust as needed.

2. How often should I microdose mushrooms for migraine relief?

A common microdosing schedule is one to four days per week. However, this can vary based on individual response and tolerance. Some people may find a schedule of dosing every third day effective, while others might prefer a regimen of four days on followed by three days off.

3. Is microdosing mushrooms legal?

The legality of microdosing mushrooms varies by country and region. In many places, psilocybin mushrooms are classified as a controlled substance and are illegal. It's crucial to be informed about the legal status in your area before considering microdosing.

4. What outcomes can I expect from microdosing mushrooms for migraines?

Individual experiences with microdosing for migraines can vary. Some people report a reduction in the frequency and intensity of migraine episodes, improved mood, and increased cognitive function. However, results are subjective and can differ from person to person.

5. Can microdosing mushrooms completely cure migraines?

Microdosing mushrooms is not considered a cure for migraines but rather a potential treatment to manage symptoms. It may help in reducing the frequency and severity of migraines but should be considered part of a broader treatment strategy that includes lifestyle changes and other therapies.

6. Are there any side effects of microdosing mushrooms for migraines?

While microdosing is generally well-tolerated, some potential side effects include mild nausea, heightened emotional sensitivity, and changes in perception. It's important to monitor your response and adjust the dosage accordingly.

7. Can I microdose mushrooms if I am on other migraine medications?

It's essential to consult with a healthcare professional before combining microdosing with other migraine medications. Psilocybin can interact with certain drugs, and a medical professional can provide guidance based on your specific situation.

8. How long does it take to feel the effects of microdosing for migraines?

The effects of microdosing can vary, with some individuals noticing changes within a few days to a couple of weeks. Consistency and patience are key, as the effects can be subtle and gradual.

9. Should I use a particular strain of mushroom for microdosing for migraines?

Different strains of psilocybin mushrooms can have varying levels of potency and effects. Research and anecdotal evidence suggest that strains with higher psilocybin content may be more effective for migraines, but personal preference and response also play a significant role.

10. Can I microdose mushrooms for migraines without supervision?

While microdosing can be done independently, it's advisable to seek guidance from a knowledgeable source, especially if you are new to the practice. Consulting with a healthcare professional or an experienced microdoser can provide valuable insights and ensure a safer experience. That being said, microdosing is quite safeas long as you are not taking certain prescription medications.

References & Additional Resources


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