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Neuro Regeneration, Psilocybin and Lion's Mane

Updated: Nov 29, 2023

Graphic of a brain showing neuronal connections lighting up

Psilocybin, a naturally occurring psychedelic compound found in certain mushrooms, has recently sparked increasing scientific interest for its potential to not only treat various mental health conditions but also promote neuroregeneration. Meanwhile, the medicinal Lion's mane mushroom has been investigated for its neuroregenerative properties. The combination of these two compounds may hold significant potential in promoting brain health and function.

Neuroplasticity & Psilocybin

Neuro regeneration is a critical process for maintaining brain health and function as it repairs and replaces damaged or lost neurons. Psilocybin has been shown to promote neuroplasticity, the brain's ability to change and adapt, by enhancing the formation of new neural connections and strengthening existing ones. This can lead to improved cognitive function and reduced symptoms of depression and anxiety.

Furthermore, Lion's mane mushroom has been found to contain compounds like hericystin and erinacine that promote the growth and repair of nerve cells. It also contains beta-glucans, which have anti-inflammatory and antioxidant properties, crucial for promoting brain health and function. (more on the science behind psilocybin)

The Synergy of Mushrooms

When combined, psilocybin and Lion's mane mushroom may promote neuroregeneration and overall brain health by enhancing neuroplasticity and nerve growth and repair. Moreover, psilocybin therapy has been linked to increased emotional openness and empathy, resulting in greater insight and understanding that can help individuals better address the underlying causes of their problems.

It is crucial to note that more research is required to fully comprehend the mechanisms by which these compounds promote neuroregeneration and the potential benefits.


Preliminary studies suggest that psilocybin and Lion's mane mushroom hold great potential in promoting brain health and function by enhancing neuroplasticity, nerve growth and repair, emotional openness, and empathy. While more research is necessary to comprehend their mechanisms fully, these compounds offer significant potential for promoting neuroregeneration. As always, it's recommended to consult a medical professional before starting any new treatment.


  • Ly et al. (2021). Psilocybin and depression: a review of the current state of knowledge. ACS Pharmacology & Translational Science, 4(3), 707-719. doi: 10.1021/acsptsci.0c00137

  • Wang et al. (2020). Hericium erinaceus polysaccharide facilitates restoration of injured intestinal mucosal immunity in Muscovy duck reovirus-infected Muscovy ducklings by modulating the NF-κB and HSP70 signaling pathways. International Journal of Biological Macromolecules, 162, 2147-2158. doi: 10.1016/j.ijbiomac.2020.09.150

  • Fang et al. (2019). The neuroprotective effects of erinacine A on SH-SY5Y cells and the underlying molecular mechanism. International Journal of Molecular Sciences, 20(4), 899. doi: 10.3390/ijms20040899

  • Mori et al. (2019). Erinacine A-enriched Hericium erinaceus mycelium ameliorates high-fat diet-induced obesity and metabolic dysfunction in mice. Food & Function, 10(12), 7751-7763. doi: 10.1039/C9FO01871D

  • Lai et al. (2013). Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. International Journal of Medicinal Mushrooms, 15(6), 539-554. doi: 10.1615/IntJMedMushr.v15.i6.30


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